FORMULATION OF CREAM PREPARATIONS FROM HANDELEUM LEAF EXTRACT (Graptophyllum pictum) AND ANTIOXIDANT ACTIVITY TEST WITH DPPH (1,1-DIPHENYL-2-PIKRILHYDRAZIL) METHOD

Abstract

Handeleum leaves as a natural herbal medicine that is efficacious as a hemorrhoid medicine, launch urination, facilitate menstruation, rheumatic drugs and ulcers. Handeleum leaf antioxidant tests from ethanol, ethyl acetate and n-butanol extracts have been carried out which have the ability to reduce DPPH free radicals with IC₅₀ values of 83.25 ppm respectively; 271.04 ppm and 385.82 ppm. This study aims to formulate G. pictum leaf extract cream preparations and test its antioxidant activity with the DPPH method. Three formulas are made, namely F0 (Base), FI (10% extract) and FII (20% extract). Physical evaluation includes organoleptis, homogeneity, pH, adhesion and dispersion. The results of the evaluation formulation cream of organoleptis preparations, homogeneity, pH, adhesion and dispersion meet the standards. The IC₅₀ value of G. pictum leaf methanol extract, which is 86.24 ppm (strong), cream (F0) has an IC₅₀ value of 1,231.30 ppm, G. pictum leaf extract cream with a concentration of 10% (FI) has an value of 800.41 ppm, and 20% (FII) has an value of 643.85 ppm. All three formulas fall into the category of having no antioxidant activity.