Correlation of Platelet Count and Liver Enzymes inDengue Hemorrhagic Fever Patients

Abstract

Introduction: Dengue Hemorrhagic Fever (DHF) is one of the endemic diseases throughout the tropics and some subtropics. DHF can affect liver enzyme levels, causing SGOT and SGPT levels in the body to increase along with the severity of DHF as indicated by a decrease in the number of platelets. A study has been conducted on the relationship between platelet values and SGOT and SGPT levels. Materials and Methods: Platelets were counted using a hematology analyzer and SGOT and SGPT activities were measured using the IFCC method. The study was conducted on 38 outpatients at the Simpang Joglo Clinic. Data were processed using SPSS 23 to obtain the relationship between each parameter. The Spearman-rho non-parametric correlation test was used to analyze this relationship. Results: A significant relationship was found between platelet valuesand SGOT activity (Sig. value 0.000 <0.05) with a strong negative correlation degree. A significant relationship was found between platelet values and SGPT activity (Sig. (2-tailed) value is 0.000 < 0.05). With a strong correlation degree (-0.608) and a negative direction: meaning that if the platelet value increases, then SGPT decreases. A significant relationship was found between SGOT activity valuesand SGPT activity, there is a significant relationship because the Sig. (2-tailed) value is 0.000 < 0.05. With a strong correlation degree (0.934) and a positive direction: meaning that if SGOT activity increases, then SGPT activity also increases. Conclusion: There is a close relationship between liver function and the severity of DHF, it is a good idea to conduct research on the relationship between albumin, globulin, and total bilirubin levels and the severity of DHF.