NONI LEAF EXTRACT (Morinda citrifolia L.) AS AN IMMUNOMODULATOR AGAINST Escherichia coli

Abstract

Noni Leaf Extract As An Immunomodulator Against Escherichia coli. In normal circumstances the body can fight exposure to pathogenic microorganisms because of the immune system present in the body, but when the immune system is reduced or inadequate exposure to pathogenic microorganisms can cause various diseases so that the body requires intake to increase immune system activity, one of which is the intake of substances that are immunomodulatory. Noni leaves have active compounds of flavonoids and steroids that can act as immunomodulators. This study aims to determine whether noni leaves can be an immunomodulatory agent against immunoglobulin M (IgM) and what is the optimum dose of noni leaf extract as an immunomodulatory agent against E. coli in mice. This study used an experimental method with the hemagglutination test method with adoses used for the extract were 100mg / 200g BB, 200mg / 200g BB and 300mg/ 200g BB. Noni leaf extract was given to male DDY mice. Further research data were processed using analysis of variance (ANOVA). The ANOVA statistical results showed that the extract dosage was significantly different and for the optimum dose Duncan post hoc test was used. The results showed that the dose of 300mg / 200g BB had increased activity of immunoglobulin M (IgM) compared to positive controls, at a dose of 100mg / 200g BB and 200mg / 200g BB. The result showed that noni leaf extract could increase the activity of immunoglobulin M (IgM) against E. coli with an optimum dose of 300mg / 200g BB.