Analysis of the Relationship Between Urea and Creatinine Levels in Type 2 Diabetes melitus patients

Abstract

Introduction:  
Diabetes mellitus (DM) is a chronic metabolic disorder characterized by persistent hyperglycemia, which may lead to microvascular complications such as diabetic nephropathy. Prolonged elevated blood glucose can damage renal structures, including the glomerular membrane, and may progress to renal failure.

Materials & Methods:
A descriptive–correlative study was conducted to analyze the association between urea and creatinine levels in type 2 DM patients. Seventy patients with fasting blood glucose ≥ 126 mg/dL were included. Urea levels were measured using an enzymatic UV method, and creatinine levels were assessed using the Jaffe method. Statistical analysis utilized the Spearman correlation test.

Results:
Participants had a mean age of 52 years (range: 46–69 years), and all were female. Mean urea and creatinine concentrations were 37 mg/dL (15–108 mg/dL) and 1.08 mg/dL (0.7–2.3 mg/dL), respectively. The data were not normally distributed. A significant correlation was observed between urea and creatinine levels (p < 0.05).

Conclusion:
There is a significant association between urea and creatinine levels in patients with type 2 DM, suggesting concurrent elevations may reflect early renal impairment.